CellMinerCDB

NCI-60 Analysis Tools

This page provides automation of several commonly done analyses. For a complete description of the CellMiner options, go to the "Home" tab above.

For a detailed description of the functionalities and how to use them, see (Reinhold, Cancer Res, 2012).

Please try our interactive site [CellMinerCDB] for exploring NCI-60 data in conjunction with data from the CCLE, CTRP, GDSC cell line datasets.

Step 1 - Select analysis type:

Cell line signature (limit 10)

Drug activity z scores (input NSC#)¹ [help]

microRNA mean values¹ [help]

Genetic variant summation (input HUGO name)¹ [help]

Gene DNA copy number (input HUGO name)¹ [help]

Gene transcript z scores (input HUGO name)¹ [help]

Gene DNA methylation values (input HUGO name)¹ [help]

RNA-seq gene expression values (input HUGO name)¹ [help]

Protein RPPA mean values (input HUGO name)¹ [help]

Protein SWATH values (input HUGO name)¹ [help]

Drug almanac combo scores (input NSC#:NSC#)¹ [help]

Cross-correlations of transcripts, SWATH protein, drugs, and microRNAs (input HUGO name, swaHUGO name, NSC and microRNA ID)¹ (limit 10)

Pattern comparison³ (limit 5) [help]

Gene transcript (HUGO) name¹

microRNA¹

Drug NSC#¹

Protein RPPA (HUGO name)¹

Protein SWATH (HUGO name)¹

60-element pattern²

Exome sequencing (DNA) graphical synopsis by gene (input HUGO name)¹

Drug vs gene variant/isoforms (inputs NSC:HUGO name)¹ [help]

¹ Identifiers and drug mechanism of action definitions. [Identifier file] [Machine readable version].

² Pattern Comparison input template [download].

³ The phenotypic parameters in Pattern Comparison [download].

Input list

Upload file

Input the identifier(s):

Examples: ABCB1 BRCA2 CNBP

Note: this will return only exact matches to the list entered.

Your results will be e-mailed to you when they are complete.