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Chk2 Molecular Interaction Map and Rationale for Chk2 Inhibitors
Yves Pommier, John N. Weinstein, Mirit I. Aladjem and Kurt W. Kohn
Clin Cancer Res. 2006 May 1;12(9):2657-61.
Abstract:
To organize the rapidly accumulating information on bioregulatory networks related to the histone
gamma-H2AX-ATM-Chk2-p53-Mdm2 pathways in concise and unambiguous diagrams, we used the molecular interaction map
notation (http://discover.nci.nih.gov/min). Molecular interaction maps are particularly useful for networks that include
protein-protein binding and posttranslational modifications (e.g., phosphorylation). Both are important for nearly all of
the proteins involved in DNA double-strand break signaling. Visualizing the regulatory circuits underlying cellular signaling
may help identify key regulatory reactions and defects that can serve as targets for anticancer drugs.
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