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Molecular Interaction Map of the Mammalian Cell
Cycle Control and DNA Repair Systems
Kohn KW
Mol Biol Cell. 1999 Aug;10(8):2703-34.
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Abstract: Eventually to understand the integrated function of the cell cycle regulatory network,
we must organize the known interactions in the form of a diagram, map, and/or database. A diagram convention was
designed capable of unambiguous representation of networks containing multiprotein complexes, protein modifications,
and enzymes that are substrates of other enzymes. To facilitate linkage to a database, each molecular species is
symbolically represented only once in each diagram. Molecular species can be located on the map by means of indexed
grid coordinates. Each interaction is referenced to an annotation list where pertinent information and references
can be found. Parts of the network are grouped into functional subsystems. The map shows how multiprotein complexes
could assemble and function at gene promoter sites and at sites of DNA damage. It also portrays the richness of
connections between the p53-Mdm2 subsystem and other parts of the network.
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